{
  "study": "NIH Tox21 Data Challenge \u2014 Ranked 5th Globally",
  "model_id": "rasayan-labs/rasayan-tox21-snn",
  "release_date": "2026-02-05",
  "global_rank": 5,
  "mean_roc_auc": 0.854,
  "endpoints": [
    {
      "endpoint": "NR-AR",
      "panel": "Nuclear Receptor",
      "target": "Androgen Receptor (Full Length)",
      "pathway": "Endocrine / Androgen Signaling",
      "Reference_Compound": "Testosterone / Nilutamide"
    },
    {
      "endpoint": "NR-AR-LBD",
      "panel": "Nuclear Receptor",
      "target": "Androgen Receptor (Ligand-Binding Domain)",
      "pathway": "Direct LBD Binding",
      "Reference_Compound": "Dihydrotestosterone"
    },
    {
      "endpoint": "NR-AhR",
      "panel": "Nuclear Receptor",
      "target": "Aryl Hydrocarbon Receptor",
      "pathway": "Xenobiotic & Dioxin Response",
      "Reference_Compound": "Benzo[a]pyrene / TCDD"
    },
    {
      "endpoint": "NR-Aromatase",
      "panel": "Nuclear Receptor",
      "target": "Cytochrome P450 19A1 (Aromatase)",
      "pathway": "Estrogen Biosynthesis Inhibition",
      "Reference_Compound": "Letrozole / Aminoglutethimide"
    },
    {
      "endpoint": "NR-ER",
      "panel": "Nuclear Receptor",
      "target": "Estrogen Receptor Alpha (Full Length)",
      "pathway": "Endocrine / Estrogen Signaling",
      "Reference_Compound": "Bisphenol A / 17beta-Estradiol"
    },
    {
      "endpoint": "NR-ER-LBD",
      "panel": "Nuclear Receptor",
      "target": "Estrogen Receptor Alpha (LBD)",
      "pathway": "Direct Estrogen LBD Binding",
      "Reference_Compound": "17beta-Estradiol / Tamoxifen"
    },
    {
      "endpoint": "NR-PPAR-gamma",
      "panel": "Nuclear Receptor",
      "target": "Peroxisome Proliferator-Activated Receptor Gamma",
      "pathway": "Lipid Metabolism & Adipogenesis",
      "Reference_Compound": "Rosiglitazone / Tributyltin"
    },
    {
      "endpoint": "SR-ARE",
      "panel": "Stress Response",
      "target": "Antioxidant Response Element (Nrf2)",
      "pathway": "Oxidative Stress & Electrophile Response",
      "Reference_Compound": "Sulforaphane / Quercetin"
    },
    {
      "endpoint": "SR-ATAD5",
      "panel": "Stress Response",
      "target": "ATPase Family AAA Domain-Containing Protein 5",
      "pathway": "DNA Replication Fork Stall & Genotoxicity",
      "Reference_Compound": "5-Fluorouracil / Cisplatin"
    },
    {
      "endpoint": "SR-HSE",
      "panel": "Stress Response",
      "target": "Heat Shock Factor Response Element",
      "pathway": "Proteotoxic & Unfolded Protein Stress",
      "Reference_Compound": "Geldanamycin / Celastrol"
    },
    {
      "endpoint": "SR-MMP",
      "panel": "Stress Response",
      "target": "Mitochondrial Membrane Potential (DeltaPsi_m)",
      "pathway": "Bioenergetic & Mitochondrial Toxicity",
      "Reference_Compound": "Rotenone / FCCP"
    },
    {
      "endpoint": "SR-p53",
      "panel": "Stress Response",
      "target": "Tumor Suppressor p53 Pathway",
      "pathway": "DNA Damage & Cell Cycle Arrest",
      "Reference_Compound": "Etoposide / Benzo[a]pyrene"
    }
  ]
}