{
  "study": "AI/ML-Assisted Computational Design and Immunoinformatics Evaluation of RasIC-01v Targeting Podoplanin in GBM",
  "doi": "10.64898/2026.02.18.706629v1",
  "published_date": "2026-02-18",
  "construct": {
    "name": "RasIC-01v",
    "length_aa": 293,
    "molecular_weight_da": 29972.34,
    "isoelectric_point_pi": 9.31,
    "instability_index": 26.27,
    "aliphatic_index": 74.61,
    "gravy": -0.328,
    "vaxijen_antigenicity": 0.7812,
    "ramachandran_favored_pct": 93.8,
    "errat_quality": 93.846,
    "prosa_z_score": -3.19,
    "codon_cai": 0.961,
    "gc_content_pct": 63.38
  },
  "tlr3_complex_metrics": {
    "pdb_receptor": "1ZIW",
    "clustpro_weighted_score": -1312.5,
    "prodigy_delta_g_kcal_mol": -18.6,
    "prodigy_kd_M": 2.3e-14,
    "hydrogen_bonds": 24,
    "salt_bridges": 2,
    "non_bonded_contacts": 259,
    "md_duration_ns": 100
  }
}