{
  "study": "ICH M7(R2)-Compliant Dual (Q)SAR System for Bacterial Reverse Mutation (RS_BMUT & RS_Expert)",
  "qmrf_date": "2026-05-14",
  "ocsr_release_date": "2026-04-29",
  "training_set_n": 8542,
  "external_test_set_n": 1890,
  "models": {
    "RS_BMUT_v2_1": {
      "methodology": "Statistical (Q)SAR Ensemble",
      "balanced_accuracy": 0.854,
      "sensitivity": 0.878,
      "specificity": 0.83,
      "roc_auc": 0.918,
      "ad_coverage": 0.942
    },
    "RS_Expert_v2_1": {
      "methodology": "Expert Rule-Based (53 Alerts + 6 Detox Rules)",
      "balanced_accuracy": 0.831,
      "sensitivity": 0.862,
      "specificity": 0.8,
      "ad_coverage": 0.965
    },
    "Combined_WoE": {
      "methodology": "Dual ICH M7(R2) Weight-of-Evidence",
      "balanced_accuracy": 0.884,
      "sensitivity": 0.926,
      "specificity": 0.842,
      "npv": 0.941
    }
  }
}